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Monday, May 7, 2018

What is Cholesterol why increased blood cholesterol is bad

Cholestrol is a steroidal molecule which has both fatty and water soluble groups on it , cholesterol is one of the essential requirement of our body , cholesterol serves as base in building cell wall of our body cells, it is used inside the cell to carry out numerous intracellular functions, Cholesterol is used in our body to synthesis Vit D ,it is used as starting material in our body in the synthesis of steroidal hormones like progesterone hormones, cortisol and aldosterone, estrogens, and testosterone, all these hormones are very important in  carrying normal functioning of our body. Cholesterol is used in making bile salts, which help in absorption of fatty food from intestine , hence when ever we eat high fatty food there is increase in cholesterol level in our blood.

Why increased cholesterol level in our blood is considered harmful.

 Increase cholesterol is first stored in liver , then in the cell wall , then it finds its way over the blood vessels , the deposition of cholesterol over blood vessels result in reduced plasticity , and then stiffness , which in turn develops in to atherosclerosis , and subsequent develops coronary heart diseases , where the blood flow to heart muscle is blocked due to formation of plaque in side coronary artery. The subsequent impact of high cholesterol is development of diabetes in most of the peoples suffering from high blood cholesterol levels. Balanced low cholesterol diet and exercise help in reducing cholesterol, in some urgent conditions, cholesterol lowering drugs are also prescribed by doctors. Role of HDL high density lipoprotein : It is also known as bad cholesterol Role of LDL Low density lipoprotein. It is also known as bad cholesterol Normal range of cholesterol is considered less than 200 mg/ dl Borderline high cholesterol Range is 200 to 239 mg/ dl High risk level of cholesterol is Greater than 240 mg/ dl There is risk of developing heart disease and stroke in person with high cholesterol level , controlled diet and regular exercise help in lowering high blood cholesterol. High blood cholesterol level is also associated with lifestyle, and job profile, in individuals who require less moment and perform less physical work are always at risk of developing high blood cholesterol level Food rich in cholesterol are animal fat, Human breast milk, egg yolks, beef, pork, poultry, and shrimp, cheese. Food which help in lowering cholesterol: Grapefruit, Oranges, and Tomato , these fruit contains flavanone, “  naringenin” which is also an antioxidant , regular intake of these fruits or consuming them raw or as juice help in reducing cholesterol. Diagnosis of Diabetes blood tests

Saturday, November 19, 2016

Gene editing toll CRISPER used first time on Human to treat lung cancer

This a first time use on humans suffering with cancer are injected with modified gene that program cell death by shutting off a gene responsible for programmed cell death (PD-1).
A gene editing tool CRISPER is used to edit gene on T lymphocytes that confer immunity against foreign pathogens foreign body and produce immunoglobulin that kill cancerous cells.
Editing gene will help to increase life of T Cells.
It is expected to work in an agonistic manner along with drug therapy and hope to get favorable results in treatment of metastatic cancer.

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