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Saturday, July 18, 2015

Why we get acidity after taking painkiller medicines

Almost all painkiller medicines are drugs which are acidic in nature, especially those belonging to nonsteroidal anti inflammatory these drug molecules are acidic in nature, these painkiller medicine after dissolving in Gastro Intestinal Tract (GIT) get absorbed in blood, start irritation where ever they come in contact, also as a positive feedback mechanism gastric acid is increased to higher extent after consumption of painkiller drugs.

Nonsteriodal painkiller drugs act by blocking synthesis of prostaglanding, a hormone which is responsible for elevating the threshold level in perception of pain.

For example lets see a very common anti inflammatory drug widely used is Ibuprofen. Ibuprofen is derivative of propanoic acid, also same is with diclofenac sodium, it is a derivative of phenylacetic acid.

Treatment for hyper acidity is done followed by intake of nonsteriodal anti inflammatory drugs by blocking synthesis of 5HT in stomack which stimulates sercretion of gastric acid, along with antacids of aluminium hydroxide and magnesium hydroxide. These antacids are basic molecules which act with gastric acid reducing its concentration.

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